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SPECIMEN COLLECTION: Fixatives

What is the difference between buffered and nonbuffered formalin?

Buffered formalin tends to produce fewer osmotic changes in the organisms during the fixation; however, on a day to day basis, it may be difficult to detect morphologic differences from buffered and nonbuffered formalin. Based on the potential benefits, most laboratories are using buffered formalin, either 5% or 10%.
 
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