IMMUNO-MYCOLOGICS, INC.
FUNGAL DIAGNOSTIC SYSTEMS AND REAGENTS :

Cryptococcus neoformans Latex Agglutination Systems | Cryptococcus neoformans Tube Agglutination Systems | Sprothrix Scheckii Latex Agglutination Systems and Reagents

In most cases of cryptococcosis, antigen concentration will exceed antibody and be detected in latex agglutination tests. However, in most cases and in some stages of the disease, antigen may not be present in excess and tests to detect antibody may be necessary to make a serological diagnosis. In Central Nervous System (CNS) cryptococcocis, antigen excess is present and detectable by latex agglutination in spinal fluid in the vast majority of the cases. During successful antifungal therapy, it is not uncommon for antigen tests to become negative and antibody tests to become positive with rising titers. In non-CNS disease (e.g., pulmonary, osteolytic, etc.), antibody tests may be the only means for making a serological diagnosis, since tests for antigen may or may not be positive.

The YA-Crypto Tube Agglutination System is based upon the principle that yeast cells of weakly encapsulated Cryptococcus neoformans strains will agglutinate with specimens containing antibodies against C. neoformans. The system detects these antibodies when present and is both qualitative and semi-quantitative. It is most effective for detecting the antibodies of C. neoformans in the serum of patients with pulmonary and extrapulmonary cryptococcosis (non-meningeal); however, the spinal fluid of cryptococcal meningitis patients may also contain detectable levels of antibody, especially during and following successful therapy.

Cryptococcus Tube Agglutination Systems

Cryptococcus Tube Agglutination Reagents